While there are different types of autoimmune diseases, they all share the same mechanism of the immune system attacking its own body and cells. This creates an inflammatory response that is similar to what our body does when we have a cold or flu.

Many of those with autoimmune diseases tend to have more than 1. Why is it so common to have multiple autoimmune diseases? Scientists believe that there are likely shared genes and similar molecular mechanisms at play.

Autoimmune Registry (ARI) is spearheading the use of the All of Us platform to incorporate genome data into our data analysis.  Information on disease prevalence, coupled with lab test results, patient-reported symptoms, and genomic data will let us develop statistical models to predict autoimmune diseases and reduce the time to diagnosis.

Many people suffer from both diseases, but which one typically comes first?

Scientists researching a case of lupus in a 7-year-old girl discovered a genetic mutation that led to her disease.  This is important news, but what does it mean for people with other autoimmune diseases or even other people with lupus?

Many people ask: “Why group all autoimmune diseases together in one registry? There are over 100 autoimmune diseases, and most people have only one.” However, data show that people with one autoimmune disease often develop another autoimmune disease.  And sometimes these connections are unexpected.